CIP/SIP Cleaning Solutions

Clean-in-place (CIP), wash-in-place (WIP) and sterilise-in-place (SIP) systems support the controlled cleaning and, where required, sterilisation of powder processing equipment. They reduce manual disassembly, cross-contamination risks and downtime while providing repeatable cycles for hygienic and aseptic production.

Hosokawa Micron integrates cleaning systems into individual machines and complete processing plants for pharmaceutical, food and other contamination-sensitive applications. Solutions can include spray devices, tank cleaners, nozzles, seals and automated sequences for rinsing, chemical washing, blowdown, drying and sterilisation. Incorporating CIP/SIP at the design stage supports cleanability, documentation and process validation.

CIP cleaning demonstration

Demonstration of a CIP cleaning process of a 2000 litre Nauta^® conical screw mixer, designed for pharmaceutical processing:

Clean-In-Place (CIP)

The primary aim of cleaning in place is to minimise contamination of the equipment during processing by designing the hygienic concept right down to the smallest details. CIP systems enable the internal surfaces of systems to be cleaned with minimal disassembly or even none at all. The fully automatic CIP process eliminates all manual cleaning tasks and the cleaning operation is performed in line with a series of predefined steps, including process times and other parameters. Alternatively, it is possible to set up a semi-automatic process, which includes some manual intervention. This is generally known as Wash-In-Place (WIP).

Sterilise-In-Place (SIP)

In the case of aseptic applications, a thorough SIP process is vital to ensure a sterile production environment. In many cases, saturated pure steam is used at high temperatures (> 121 °C) without an autoclave to destroy any microorganisms that could otherwise remain in the system.

Implementing CIP/SIP

The most effective way to implement CIP/SIP technology is to incorporate it into the production equipment at the design stage. At Hosokawa Micron, we offer an extensive range of technology that can be included in a CIP or SIP solution, ranging from spray systems and tank cleaners to nozzles and seals. We consider every aspect of your system when designing the optimal solution to automate the wet-cleaning process, from inlet to discharge. Besides that, the overall functionality can also be integrated in a complete functional system including configurable programs for water rinses, chemical washes, blowdown and air drying, sanitation (based on heat or chemicals), flow control, pressure, concentration and temperature.

Suncombe cleaning systems

In the field of cleaning systems and decontamination solutions, we have partnered with the renowned British company Suncombe Ltd. Suncombe operates worldwide, particularly in the pharmaceutical and biomedical industries. For the Netherlands, Hosokawa Micron B.V. represents Suncombe's complete range of products and services, including CIP installations, GMP cleaning systems, decontamination solutions and specialist skid-mounted process equipment.

Effluent Decontamination Systems

Suncombe BioWaste Effluent Decontamination Systems (EDS) decontaminate liquid hazardous infectious waste streams from manufacturing, laboratory research and bio-containment environments. These systems can also be referred to as Effluent BioWaste Treatment Plant Solutions (ETP). Using robust, proven design principles, Suncombe BSL processes Bio Safety Level 1 to 4 waste.

Suncombe systems are available for thermal, thermochemical and chemical inactivation. Thermal inactivation can be carried out using steam, superheated water or a recognised electrical heating technique that minimises time and space.

For more information on Suncombe's EDS solutions, please visit www.suncombe.com.